Yuuji Itadori is a high schooler who spends his days either with his Occult Club or visiting his bedridden grandfather at the hospital. One day, he unknowingly encounters a cursed item, which triggers a chain of supernatural occurrences. It turns out the cursed item is a finger belonging to the demon Sukuna Ryoumen, the "King of Curses". Now, Yuuji has to face the threat of Curses, which are dreadful beings formed from human malice and negativity.
He discovers he has newfound powers, and is introduced to the Tokyo Metropolitan Jujutsu Technical High School. He now has to embark on a path of a Jujutsu sorcerer, from which he cannot return.
Jujutsu Kaisen follows Yuuji's journey as he learns to use his powers to fight the Curses, and protect society from their threat.